Invokana - Side effects, FDA Warnings, Drug interactions & Lawsuits


This is an oral diabetes drug that controls the blood sugar levels in the patient and it helps the kidneys remove glucose from the blood. The lawsuit against this drug states that the manufacturers did not give the patients and physicians enough warning that the drug can causes kidney failure, sexual function problem, and also loss of limbs.

What is an Invokana?

Invokana is a canagliflozin which is a SGLT2 inhibitor, i.e. it is a type of drug that helps in the lowering of the blood glucose levels in those individuals who suffer from diabetes. The FDA approved this drug in March 2013, this was the first drug in its class. This works by allowing higher amounts of sugar to be excreted out in the urine. Although it is a very useful drug when it comes to lowering blood sugar levels it is known to have severe side effects that include cardiovascular diseases, diabetic ketoacidosis and other kidney health issues. There have also been certain studies that have linked the use of this drug to an increased risk of amputation of limbs.
Some individuals had such severe side effects that they needed to be hospitalized whereas others were permanently disabilitated.
Due to these reasons those individuals who suffered the ill effects of this drug decided to file lawsuits against Janssen Pharmaceuticals along with its parent company Johnson & Johnson for failing to provide the appropriate warning to the consumers and doctors about these risks.

Side effects of Invokana

The numerous side effects that are caused due to the consumption of Invokana are as follows

  • Injury to kidney and kidney failure
  • Urinary tract infection
  • Heart attacks and other cardiovascular diseases
  • Limb amputation
  • Diabetic ketoacidosis

Other minor side effects included

  • Dehydration and thirst
  • Discomfort while urinating
  • Frequent urination
  • Increased cholesterol
  • Low blood sugar
  • Fatigue
  • Yeast infection
  • Constipation
  • Nausea
  • Abdominal pain
  • Vaginal itching

Researchers have not been able to correctly identify what causes these side effects but they suspect that it is related to the manner in which this drug affects the vascular system. Cell death can be caused due to the lack of oxygen to the extremities in the body. Due to this even a minor injury can cause life threatening. If you or a loved one has been taking this drug and experience any unusual symptoms it is very important that you consult a doctor as soon as possible.

FDA Warnings

Since 2015, the FDA realised the risks that were associated with the use of this drug and sent out multiple warnings about the potential health hazards that are caused due to this drug.
The agency also required that the manufacturers add a black box warning to the packaging of the drug to warn the doctors and also the patients who are prescribed this drug about the health risks that they could be putting themselves in.

Drug interactions

Invokana is also known to interact with different drugs such as

  • UGT enzyme inducers
  • Digoxin
  • Insulin

It was also found that the drug interacted in different individuals in different ways the most important of these contraindications were found in pregnant women, nursing mothers, children, and in seniors.


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