Xarelto is an anticoagulant drug that is mainly used to prevent or treat blood clots in the legs that is known as deep vein thrombosis (DVT) which may also cause pulmonary embolisms, i.e., blood clots in the lung. The most common and dangerous side effect of Xarelto was that it internal bleeding in the individual and since its approval in 2011 the FDA made required that the label include a black box warning that has been changed multiple times over the years.
Xarelto is a rivaroxaban that helps to block the activity of the clotting substances in the blood. This drug is used mainly to treat deep vein thrombosis (DVT) that is a type of blood clot that forms in the leg but can break away and make its way to other organs of the body such as the lungs or heart.
In addition to DVT this drug is also used for people who suffer from atrial fibrillation which is a heart rhythm disorder; Xarelto helps to lower the risk of strokes that are caused in these people.
Working of Xarelto
This drug affects a specific protein called Factor Xa that is present in the blood and helps with the process of blood clotting. Once this protein is blocked it hampers the production of the enzyme “thrombin” and thus stops the blood clot from forming. It takes 24 hours for this drug to get flushed out of the system however it can stay longer in individuals that are older.
Who should not use Xarelto?
Symptoms of the side effects of Xarelto
Immediately call for emergency medical help if you have the following symptoms.
- Back pain
- Numbness of lower body
- Muscle weakness in lower body
- Loss of bladder or bowel control
Talk to your doctor if you have
- Easy bruising or bleeding
- Swelling, pain, or draining from the injection site
- Any bleeding that will not stop
- Dizziness, headaches, blackouts and weakness
- Red, pink or brown color urine
- Bloody stool, coughing blood, or vomit that looks like coffee grounds
- Muscle pain
- Pain in limbs
To avoid any such side effects it is important that you keep your doctor informed about any disease that you are suffering from.
The effect of this drug on unborn babies is not clear at this moment; however, it may cause a significant bleeding complication during childbirth. Thus it is also important that you inform your doctor if you are pregnant or of any plans of getting pregnant while using this drug. Also it is unknown whether or not this drug can be passed to a new born baby through breast milk. Hence, you should also avoid taking this medication while breast feeding or do not nurse your child while on this drug.
Xareltos interaction with other drugs
Before taking Xareto in any form it is important that you inform your doctor if you are taking any sort of medication. The list of drugs that interact with Xarelto are as follows and you may have to stop the use of some of these drugs if you have to take Xarelto.
- John’s wort
- Any form of antifungal medication such as itraconazole or ketoconazole
- Medication for HIV like indinavir, lopinavir, or ritonavir
- Medication for seizures such as carbamazepine, Phenobarbital, or phenytoin
However, a complete list cannot be provided here and it is always best to consult with your doctor.
The FDA approved the use of this drug in 2011. Since then, there have been multiple changes in the label of this medication. The FDA said that a black box warning was needed to be added to the packaging of this drug so that any patient who uses it wiFDA warning.
ll know about the possible risks of this medication. The most recent update to the black box warning was in May 2016.